Model validation with experimental results.

<p>(A): Comparison between our model-predicted, spatially averaged PCr/ATP ratio vs V<sub>O2</sub> with model predictions from Vendelin et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006640#pcbi.1006640.ref013" target="_blank">13</a>] and experimental results from Valdur Saks et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006640#pcbi.1006640.ref028" target="_blank">28</a>] (B): Comparison between our model predictions for spatially averaged ADP vs V<sub>O2</sub> with predictions from Vendelin et al.’s [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006640#pcbi.1006640.ref013" target="_blank">13</a>] zero dimensional model (C): Comparison between model predicted radial profiles of O<sub>2</sub> with intracellular PO<sub>2</sub> levels calculated by Takahashi et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006640#pcbi.1006640.ref029" target="_blank">29</a>] in six different isolated cells.</p>