Model validation with experimental results.

(A): Comparison between our model-predicted, spatially averaged PCr/ATP ratio vs VO2 with model predictions from Vendelin et al. [13] and experimental results from Valdur Saks et al. [28] (B): Comparison between our model predictions for spatially averaged ADP vs VO2 with predictions from Vendelin et al.’s [13] zero dimensional model (C): Comparison between model predicted radial profiles of O2 with intracellular PO2 levels calculated by Takahashi et al. [29] in six different isolated cells.