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Metal‐Free Regioselective Chloroazidation of Internal Alkynes
Version 2 2019-01-29, 07:54
Version 1 2019-01-29, 07:52
preprint
posted on 2019-01-29, 07:54 authored by Bin Huang, Raphael Liffert, Anthony Linden, Karl GademannKarl GademannThis is a preprint of a manuscript published at Chem. Eur. J. 2019, 25, 981. DOI: 10.1002/chem.201805320
Abstract:
A metal‐free, room temperature protocol for the regioselective chloroazidation of internal alkynes is disclosed. The reactions of internal alkynes with trimethylsilyl azide (TMSN3) in the presence of 1,3‐dichloro‐5,5‐dimethylhydantoin (DCDMH) afforded the corresponding chloroazidoalkenes in good yields. This reaction has good functional group tolerance and is operationally simple.
