Metal-Free Borane-Catalyzed Highly Stereoselective Hydrogenation of Pyridines

2013-09-04T00:00:00Z (GMT) by Yongbing Liu Haifeng Du
A metal-free direct hydrogenation of pyridines was successfully realized by using homogeneous borane catalysts generated from alkenes and HB­(C<sub>6</sub>F<sub>5</sub>)<sub>2</sub> via in situ hydroboration. The reaction affords a broad range of piperidines in high yields with excellent cis stereoselectivities.