Mediation (indirect) effect of Metabolic Biomarker Levels on the relationship between IGFs/IR–relevant SNPs and CRC risk, stratified by obesity status<sup>‡</sup> and physical activity level.

<p>Mediation (indirect) effect of Metabolic Biomarker Levels on the relationship between IGFs/IR–relevant SNPs and CRC risk, stratified by obesity status<sup><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0186296#t001fn003" target="_blank">‡</a></sup> and physical activity level.</p>