Means (±SE) for behaviors directed toward the male dummy stimulus.

<p>The amount of time (sec) males in the low-dose (LD; 40 μg/L metformin), high-dose (HD; 80 μg/L metformin), and the control groups (C; no metformin exposure) spent <b>gill flaring</b> in each of three sequences of identical behavioral assays (pre-exposure, 4 weeks exposure, and 20 weeks exposure). Letter designations (a and b) correspond with significant p-values presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0197259#pone.0197259.t001" target="_blank">Table 1</a> and indicate significant differences among the low-dose, high-dose, and control group means within a given time period of testing (e.g. comparing the HD vs LD vs C group responses after four weeks exposure) (See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0197259#pone.0197259.t001" target="_blank">Table 1</a> for statistical results).</p>