Mapping of rare variants to diacylglycerol lipase alpha.

The location of rare coding variants relative to domains of the enzyme and regulatory phosphorylation sites are indicated, based on NCBI Reference Sequence: NP_006124.1. Red dot: rare variant; purple dots: two variants present in one subject; T (light green shading): transmembrane domain; light blue shading: lipase domain; A (purple shading): Active site; N (magenta shading): Nucleophilic elbow; blue vertical lines: phosphorylation sites.