Manhattan and QQ plot of joint age-stratified 2df P-values.

Shown are the age-joint P-Values (P_Agejoint) for late AMD by their position on the genome (Manhattan plot) as well as their distribution (QQ plot). In the Manhattan plot, the 34 known genetic regions identified by Fritsche et al [13] are colored blue and additional genome-wide significant signals are colored red. The QQ plot shows the distribution of P_Agejoint including all variants (black) as well as after exclusion of known loci (34 variants +/-500kb, red).