pone.0204305.g002.tif (343.89 kB)
MMP tracer quantification results.
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posted on 2018-10-10, 20:10 authored by Robert Seifert, Michael T. Kuhlmann, Sarah Eligehausen, Friedemann Kiefer, Sven Hermann, Michael SchäfersQuantification of fluorescence intensity 3 h post injection of Cy5.5-AF443 (n = 17) or the non-targeted control dye Cy5.5-glycin (n = 5). Absolute in situ MMP tracer uptake [AU] (A). P/B (plaque to background) ratios of the MMP tracer (B) and of the non-targeted control dye (C). MMP tracer correlation of in situ to ex vivo findings (D) as well as of P/B ratios to plaque size (E) (n = 6). For panel A, B and C, paired t-tests were performed.
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CCAMMP -9 activitiesplaque phenotypesMMP -2 concentrationsMMP activity discriminatesDS plaquesshear stress-induced atherosclerosisMMP -2MMP inhibitor-based fluorescencevivo fluorescence reflectance imagingmurine atherosclerosis Purposeatherosclerotic plaque rupturesELISA1.06 plaque-to-background ratioMMP -9 concentrationsMMP inhibitor-based photoprobe Cy 5.5-AF
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