jo501909w_si_001.cif (15.78 kB)
Lewis Base-Promoted Rearrangement of Allylic Cyanohydrins: Construction of Functionalized Nitriles Bearing 1,3-Diketone Moieties
dataset
posted on 2014-11-21, 00:00 authored by Yan-Jing Zhang, Qi-Lan Hou, Hai-Jing Wang, Wei-Wei LiaoA novel
Lewis base-promoted rearrangement of allylic cyanohydrins
has been developed, in which the cyano group was rearranged, directly
coupled with the generation of new functional groups. This protocol
provides a unique and facile way to prepare highly functionalized
nitriles bearing 1,3-diketone moieties under mild reaction conditions.
Furthermore, the synthetic transformations of the functionalized products
have also been demonstrated.