Lewis Acid-Catalyzed,
Copper(II)-Mediated Synthesis
of Heteroaryl Thioethers under Base-Free Conditions

Dai, Chao; Xu, Zhaoqing; Huang, Fei; Yu, Zhengkun; Gao, Yan-Feng

doi:10.1021/jo202624s.s001

jo202624s_si_001.pdf (1.86 MB)

Lewis Acid-Catalyzed, Copper(II)-Mediated Synthesis of Heteroaryl Thioethers under Base-Free Conditions

journal contribution

posted on 2016-02-21, 12:32 authored by Chao Dai, Zhaoqing Xu, Fei Huang, Zhengkun Yu, Yan-Feng Gao

A Lewis acid (Ag^I, Ni^II, or Fe^II) catalyzed, Cu^II-mediated thiolation reaction between heteroarenes and thiols was achieved with good yield under base-free conditions. DMSO could serve as an effective methylthiolation reagent for the synthesis of heterocyclic methyl thioethers.