Ar431-6.jpg (54.58 kB)
Involvement of TNF ligand family members in physiological and pathological bone resorption
figure
posted on 2011-12-30, 22:12 authored by Nobuyuki Udagawa, Shigeru Kotake, Naoyuki Kamatani, Naoyuki Takahashi, Tatsuo SudaCopyright information:
Taken from "The molecular mechanism of osteoclastogenesis in rheumatoid arthritis"
Arthritis Research 2002;4(5):281-289.
Published online 12 Apr 2002
PMCID:PMC128939.
Copyright © 2002 BioMed Central Ltd
RANKL appears to play a major role in physiological bone resorption. In contrast, both RANKL-dependent and RANKL-independent pathways appear to be involved in pathological bone resorption. At present, the contribution ratio of the RANKL-dependent and RANKL-independent pathways to the pathological bone resorption is not known. M-CSF, macrophage colony-stimulating factor.