Investigation into Sonogashira reaction on 5-iodo-1-(phenyl/<i>p</i>-halophenyl)imidazole-4-carbonitrile compounds

2017-11-16T14:17:16Z (GMT) by Aniruddha Das
<p>Investigation into Sonogashira reaction on 5-iodo-1-(phenyl/<i>p</i>-halophenyl)imidazole-4-carbonitrile compounds had been developed by introducing an iodo atom at the C-5 position of the imidazole ring of 5-amino-1-(phenyl/<i>p</i>-halophenyl)imidazole-4-carbonitrile compounds. Specifically, 5-iodo-1-(4-iodophenyl)imidazole-4-carbonitrile compound had shown double Sonogashira coupling reactions with two differently substituted iodine along with the formation of two other compounds where an unusual coupling product with self-aggregation property was obtained. In other cases, monocoupling had been observed together with another compound where iodine atom present at C5 position of imidazole was replaced by hydrogen atom.</p>