Intraperitoneal treatment with imatinib suppresses mast cell-independent MSU crystal-induced acute arthritis.

<p>(<b>A</b>) Changes in ankle thickness after i.a injection of 0.5 mg MSU in mast cell-deficient <i>Kit</i><sup><i>W-sh/W-sh</i></sup> mice (<i>n</i> = 6/group) pre-treated with imatinib (100 mg/kg) or PBS twice a day starting 24 h before the injection of MSU crystals. Data are shown as means ± SEM of data pooled from the two independent experiments performed. *** = <i>P</i> < 0.001 <i>vs</i>. indicated group by repeated measures two-way ANOVA. (<b>B</b>) H&E-stained sections of ankle showing MSU injection sites 24 h after injection of 0.5 mg MSU crystals in <i>Kit</i><sup><i>W-sh/W-sh</i></sup> mice pre-treated with imatinib (100 mg/kg) or PBS. Original magnification: x20.</p>