Intermolecular/Intramolecular Sequential Aldol Reaction

2014-01-29T00:00:00Z (GMT) by Atsuto Izumiseki Hisashi Yamamoto
The first example of intermolecular/intramolecular sequential aldol reaction of disilyl enol ethers is described. This strategy enables the formation of five-, six-, and seven-membered ring products. Four or more contiguous stereogenic centers are created with high levels of relative stereochemical control.