Inhibition effect of phenyl compounds from the <i>Oryza sativa</i> roots on melanin production in murine B16-F10 melanoma cells

<div><p>Five phenyl compounds, vanillin (<b>1</b>), methyl <i>trans</i>-ferulate (<b>2</b>), <i>trans</i>-<i>p</i>-coumaric acid methyl ester (<b>3</b>), <i>N</i>-benzoyltryptamine (<b>4</b>), and <i>N</i>-(<i>trans</i>-cinnamoyl)tryptamine (<b>5</b>), were isolated from the roots of <i>Oryza sativa</i> L. and identified on the basis of spectroscopic data. Compounds <b>3</b> and <b>5</b> showed strong inhibition effect on melanin production in murine B16-F10 melanoma cells and tyrosinase activity. Also, the quantitative analysis of the compounds was carried out using LC/MS/MS experiment. Compounds <b>3</b> and <b>5</b> could be used as skin-whitening agents.</p></div>