Fig 3.tif (3.3 MB)
Increased frequencies and absolute numbers of effector memory CD4+ T cells in cancer septic animals relative to previously healthy septic controls.
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posted on 2018-01-16, 18:38 authored by Jianfeng Xie, Jennifer M. Robertson, Ching-wen Chen, Wenxiao Zhang, Craig M. Coopersmith, Mandy L. FordCD4+ T cells isolated from splenocytes of previously healthy or cancer septic animals were analyzed by flow cytometry. A, Representative flow plots of CD44 and CD62L expression. Frequencies (B) and absolute numbers (C) of naïve, central memory, and effector memory T cells from previously healthy vs. cancer septic animals. D, Representative flow plots of CD69 and CD25 expression. Frequencies (E) and absolute numbers (F) of CD25+ and CD69+ CD4+ T cells from previously healthy vs. cancer septic animals. n = 11/group. ***p<0.001.
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Spanning-tree Progression Analysiscancer hostsT cell compartmentsT cell activation24 h post CLPage-matched non-cancer controlsPre-existing malignancy resultsT cell compartmentPDmemory CD 4ïve CD 4CD 4sepsis2 B 4LLC 1 tumor cellsmurine hosts results2 B 4 hi BTLA hi LAG -3 hi populationT cell responsesT cellsTNFcancer mice
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