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Incorporation of a Theranostic “Two-Tone” Luminescent Silver Complex into Biocompatible Agar Hydrogel Composite for the Eradication of ESKAPE Pathogens in a Skin and Soft Tissue Infection Model
journal contribution
posted on 2018-05-18, 19:16 authored by Miguel N. Pinto, Jorge Martinez-Gonzalez, Indranil Chakraborty, Pradip K. MascharakMicrobial invasion
and colonization of the skin and underlying soft tissues are among
the most common types of infections, becoming increasingly prevalent
in hospital settings. Systemic antibiotic chemotherapies are now extremely
limited due to emergence of drug-resistant Gram-positive and multidrug-resistant
Gram-negative bacterial strains. Topical administration of antimicrobials
provides an effective route for the treatment of skin and soft tissue
infections (SSTIs). Therefore, the development of new and effective
materials for the delivery of these agents is of paramount importance.
Silver is a broad-spectrum antibiotic used for the treatment and prevention
of infections since ancient times. However, the high reactivity of
silver cation (Ag+) makes its incorporation into delivery
materials quite challenging. Herein we report a novel soft agar hydrogel
composite for the delivery of Ag+ into infected wound sites.
This material incorporates a Ag(I) complex [Ag2(DSX)2(NO3)2] (1; DSX = 5-(dimethylamino)-N,N-bis(pyridin-2-ylmethyl) naphthalene-1-sulfonamide)
that exhibits a change in fluorescence upon Ag+ release
and qualitatively indicates the end point of silver delivery. The
antibacterial efficacy of the material was tested against several
bacterial strains in an SSTI model. The complex 1–agar
composite proved effective at eradicating the pathogens responsible
for the majority of SSTIs. The theranostic (therapeutic/diagnostic)
properties coupled with its stability, softness, ease of application,
and removal make this material an attractive silver-delivery vehicle
for the treatment and prevention of SSTIs.
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tissue infectionsSoft Tissue Infection Model Microbial invasionSystemic antibiotic chemotherapieswound sitesend pointsilver deliverySSTI modelagar hydrogelDSXhospital settingsdelivery materialssilver cationdrug-resistant Gram-positiveBiocompatible Agar Hydrogel CompositeESKAPE PathogensAg 2strainsilver-delivery vehiclebroad-spectrum antibioticTopical administrationprevention
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