Fig 2.tif (194.3 kB)
Impact of male circumcision on coronal sulcus IL-8 detection.
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posted on 2016-11-29, 04:30 authored by Jessica L. Prodger, Ronald H. Gray, Brett Shannon, Kamnoosh Shahabi, Xiangrong Kong, Kate Grabowski, Godfrey Kigozi, Fred Nalugoda, David Serwadda, Maria J. Wawer, Steven J. Reynolds, Cindy M. Liu, Aaron A. R. Tobian, Rupert KaulIL-8 was measured in coronal sulcus swabs taken at enrolment (time = 0), and at month 6, 12 and 24 follow-up visits. Enrolment swabs were collected prior to surgery for men randomized to receive immediate circumcision (n = 80); control men remained uncircumcised (n = 80). The proportion of men with detectable IL-8 and 95% CIs (Fisher’s exact) is presented, with prevalence risk ratio (PRR) compared to baseline, and adjusted PRR (aPRR), below. * p-value for PRR comparing prevalence of IL-8 detection between controls and circumcised men is <0.001.
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Coronal sulcus chemokine levelsCD 4 T cells subsetsMIGCD 4 T cellspenile inflammation increases HIV susceptibilityPRRcircumcisionPenile Coronal Sulcus CorrelateHIV target cell densitytissue neutrophil densitycoronal sulcus Interleukin -8CIprepuce IL -8Coronal sulcus cytokine levelsHIV susceptibility
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