IL-1R signaling makes an important contribution to neutrophil recruitment to the oral mucosa.

(A) CD45⁺ Ly6C^int Ly6G⁺ neutrophils were quantified by flow cytometry in the tongues of naïve (n) and C. albicans infected (inf) WT mice 24 hours post-infection. (B) Neutrophils were quantified in the tongues of infected WT and Il1r1^-/- mice 24 hours post-infection. (C) The fungal burden in the tongues of infected WT and Il1r1^-/- mice was determined on day 3 post-infection. Each symbol represents an individual mouse, and the lines represent the geometric mean of each group. The dotted line represents the detection limit. Data are pooled from two (B) or representative of three (A) or two (C) independent experiments. Statistical analysis was performed using log₁₀ transformation and Student’s t-test with Welch’s correction.