Table 1.xls (5.5 kB)
IC50s of human DIPG cell models with Panobinostat treatment.
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posted on 2017-01-04, 18:35 authored by Tammy Hennika, Guo Hu, Nagore G. Olaciregui, Kelly L. Barton, Anahid Ehteda, Arjanna Chitranjan, Cecilia Chang, Andrew J. Gifford, Maria Tsoli, David S. Ziegler, Angel M. Carcaboso, Oren J. BecherIC50s of human DIPG cell models with Panobinostat treatment.
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Pre-Clinical Studyvivo analysesH 3.3-K tumorsH 3.3-WT expressionpanobinostat potentlybrainstem gliomaPDGF-Btarget inhibitionBSG mouse modelhistone deacetylase inhibitorbrain tumor-related deathspontine gliomabrain tissuemurine DIPG cellstumor cellsimpact survivalvivo efficacy studiesH 3.3-K orthotopic DIPG xenograft modelwell-tolerated dosescell proliferationp 53 lossvehicle-treated micetumor-bearing miceorthotopic xenograft modelsdose de-escalationGenetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models Background Diffusemurine tumor cellsH 3 acetylationectopic H 3.3-Kbrainstem tumor tissue
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