Hypocrol A, a new tyrosol derivative from a sponge-derived strain of the fungus <i>Hypocrea koningii</i>

<p>In continuation of our search for new antibacterial and antioxidant metabolites from sponge-derived fungi, one new tyrosol derivative, hypocrol A (<b>1</b>), together with four known congeners, trichodenol B (<b>2</b>), 4-hydroxyphenethyl acetate (<b>3</b>), 4-hydroxyphenethyl tetradecanoate (<b>4</b>) and 1-oleyltyrosol (<b>5</b>), was isolated from the strain <i>Hypocrea koningii</i> PF04. Their planar structures were unequivocally elucidated by spectroscopic methods and comparison with the literature data. All the compounds displayed weak antibacterial activities against <i>Staphylococcus aureus</i>, methicillin-resistant <i>S. aureus</i> and <i>Escherichia coli</i>, whereas compounds <b>1</b> and <b>2</b> exhibited a moderate antioxidant efficacy in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay with IC<sub>50</sub> values of 48.5 and 97.4 μg/mL, respectively.</p>