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Hydrogen Bond Basicity of the Chlorogroup; Hexachlorocyclohexanes as Strong Hydrogen Bond Bases
journal contribution
posted on 2002-05-23, 00:00 authored by Michael H. Abraham, Kei Enomoto, Eric D. Clarke, Graham SextonA simple chloroalkane or chlorocycloalkane has a very small hydrogen bond basicity, B = 0.1 units.
Since B is often an additive function, it is possible that polychloro-alkanes or -cycloalkanes could
have quite large hydrogen bond basicities. Literature data on the 1,2,3,4,5,6-hexachlorocyclohexanes
(HCHs) have been analyzed by Abraham's linear free energy relationships to obtain solvation
descriptors. These are not extraordinary except for the hydrogen bond basicity, B, which is indeed
very large. Values of B for the HCHs are larger than many functionally substituted aliphatic
compounds and as large as that of aliphatic amines. We find that B is 0.62−0.72 for the HCHs
compared to 0.45 for propanone and 0.70 for ethylamine, the first time that such large hydrogen
bond basicities have been identified in compounds with no functional groups. Hydrogen bond
basicities are analyzed in order to examine what types of polychlorocompounds give rise to these
elevated B values.
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