jo6b01179_si_001.pdf (7.31 MB)
Hydroformylation of Olefinic Derivatives of Isosorbide and Isomannide
journal contribution
posted on 2016-07-29, 00:00 authored by Piret Villo, Livia Matt, Lauri Toom, Ilme Liblikas, Tõnis Pehk, Lauri VaresThe first time application
of hydroformylation on olefinic derivatives
of isosorbide and isomannide is shown by which a new carbon–carbon
bond is formed. Depending on the ligand and reaction conditions used,
the C6 regioisomer a can be obtained in 4:1 ratio and
excellent yield, whereas C5 isomer b is achieved in almost
complete regioselectivity (46:1) and good yield. In the majority of
cases only the exo orientation is observed for the
obtained aldehydes, and the method is easily applicable also on a
1 g scale.