Hydroformylation of Olefinic Derivatives of Isosorbide and Isomannide

The first time application of hydroformylation on olefinic derivatives of isosorbide and isomannide is shown by which a new carbon–carbon bond is formed. Depending on the ligand and reaction conditions used, the C6 regioisomer <b>a</b> can be obtained in 4:1 ratio and excellent yield, whereas C5 isomer <b>b</b> is achieved in almost complete regioselectivity (46:1) and good yield. In the majority of cases only the <i>exo</i> orientation is observed for the obtained aldehydes, and the method is easily applicable also on a 1 g scale.