Host-mycobacteria interactions.

Summary of the factors identified in this study with an impact on host-pathogen interactions. Mycobacteria manipulate host immune response by reducing the production of immune system proteins. However, as infection progresses, wild boar immune response recovers to limit pathogen multiplication and promote survival, facilitating pathogen transmission. Increased host survival in adult animals is probably associated with reduction in anemia progression. The upregulation of C3 may be associated with protection in uninfected adult wild boar while higher lesion score in TB++ animals could be due to infection with M. bovis spoligotypes such as SB0134.