Histopathology of TP53-mutant pig tumors stained with hematoxylin and eosin.

A: Variations in the collagenous fiber levels among tumor cells (arrowheads) of a malignant fibrous histiocytoma were detected in pig #5. Mitotic figures were also observed (arrow). B: Nephroblastoma of pig #6. Glomeruloid bodies reminiscent of the fetal nephron (arrowhead) were observed in tumor tissues. Tubular structures mainly composed of neoplastic epithelial cells (arrows) were observed. C: Osteosarcoma of pig #1. Pleomorphic non-epithelial cells forming osteoids (arrowheads) and trabecular bone (arrows) in osteosarcoma. The scale bar in each panel (A-C) indicates 100 μm.