Fig 10.TIF (2.25 MB)
HMNE3 decreased the activity of c-Src and the cellular stress response.
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posted on 2016-10-19, 17:50 authored by Yong-Chao Ma, Zhi-Xin Wang, Shao-Ju Jin, Yan-Xin Zhang, Guo-Qiang Hu, Dong-Tao Cui, Jiang-Shuan Wang, Min Wang, Fu-Qing Wang, Zhi-Jun Zhao(A) The activity of c-Src was significantly inhibited by HMNE3 in a dose- and time-dependent manner (B). The expression levels of cell stress response-related proteins and proteins that regulate apoptosis were detected by western blotting (C).
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HMNE 3TUNELHRPtopoisomerase II activityreceptor tyrosine kinasetyrosine kinaseHMNE 3 dosestumor cell proliferationterminal deoxynucleotidyl transferasetopoisomerase II proteinsRTKDNA plasmid pBR 322agarose gel electrophoresisHoechst 33258 fluorescence staining3.2 μ M HMNE 3Human Pancreatic Cancer Cellsnovel bis-fluoroquinolone chalcone-liketopoisomerase IIIC 50 valuecancer cell linesNovel Bis-Fluoroquinolone Chalcone-Liketyrosine kinase activityMTT
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