Genome-wide map of the <i>Streptococcus pneumoniae</i> TIGR4 transcriptional landscape.

<p>A map of all the transcriptional features identified. <b>1</b>. Paired-end RNA-Seq coverage of the plus strand. <b>2</b>. Paired-end RNA-Seq coverage of the minus strand. <b>3</b>. Annotated operon structures on the plus strand. Tile colors represent classification of the operons according to their number of high confidence TSS and TTSs: 1) traditional operons consisting of multiple genes with a single TSS and a TTS (green); 2) multiTSS operons consisting of multiple genes with internal TSSs but one TTS (blue); 3) multiTTS operons consisting of multiple genes with a single TSS but multiple internal TTSs (red); and 4) complex operons consisting of multiple genes with multiple internal TSSs and TTSs (orange). To avoid clutter, simple operons consisting of a single gene with a single TTS and TSS are omitted. <b>4</b>. Annotated operon structures on the minus strand. <b>5</b>. 141 novel putative intergenic regulatory elements in blue. <b>6</b>. 742 high confidence transcriptional start sites (TSS) in green. <b>7</b>. 1864 enriched transcriptional termination sites (TTS) in red. <b>8</b>. Log transformed processed/unprocessed ratio of each high confidence TSS. <b>9</b>. Log transformed coverage of each predicted TTS. <b>10</b>. Positions of the known structured non-coding RNAs and small RNAs. Figure was generated using Circos [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1007461#ppat.1007461.ref079" target="_blank">79</a>].</p>