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GL261-injected WT mice (solid line) and C57BL/6 TCR-δ-/- mice (B6.129P2-TCR-δtm1Mom/J) (dashed line) received intracranial injections of 5.0 x 105 GL261 cells and were monitored for survival.

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posted on 2015-05-08, 13:36 authored by Benjamin H. Beck, Hyunggoon Kim, Rebecca O’Brien, Martin R. Jadus, G. Yancey Gillespie, Gretchen A. Cloud, Neil T. Hoa, Catherine P. Langford, Richard D. Lopez, Lualhati E. Harkins, Lawrence S. Lamb Jr.

Median survival for TCRδ-/- mice was no different than WT, showing that the absence of γδ T cells does not significantly effect survival.

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    Circulating γδ T cells transientlyWT micesyngeneic WT C 57BL miceNKG 2D ligands expressionIFNTCRtumor growth inhibitionGL 261 intracranial gliomasT cell receptor repertoireupregulated Annexin V expressionγδ T cells 15 mimmunocompetent mouse modelV δ1 subsetsγδ T cell expansionγδ T cellssyngeneic GL 261 gliomasV δ4 populationT cell invasionglioma cell linesImmunocompetent Mouse Modelγδ T cell countILend stage

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