GC×GC/qMS analyses of <i>Campomanesia guazumifolia</i> (Cambess.) O. Berg essential oils and their antioxidant and antimicrobial activity

<p>The present study investigated the essential oil obtained from <i>Campomanesia guazumifolia</i> (Cambess.) O. Berg, an aromatic plant used in Brazilian folk medicine. The chemical composition was performed by GC×GC/qMS. The antioxidant and antimicrobial activities were evaluated by DPPH and BCB and, MIC assays, respectively. Sixty-eight compounds were identified in the oil, where the major compounds were bicyclogermacrene (15%), globulol (5%) and spathulenol (5%). Sesquiterpene hydrocarbons (29 compounds) and oxygenated sesquiterpenes (20 compounds) were the most representative classes of terpenes. DPPH (IC<sub>50</sub> value 26.1 ± 0.5 μg/mL) and BCB (68.3 ± 1.5%) values indicated a significant antioxidant activity. The essential oil strongly inhibited <i>Staphylococcus aureus</i> (MIC 15 ± 0.1 μg/mL), <i>Escherichia coli</i> (MIC 25 ± 0.2 μg/mL) and <i>Candida albicans</i> (MIC 5 ± 0.1 μg/mL). The results give a deeper understanding of the chemical composition and report for the first time the antioxidant and antimicrobial potential of the <i>C. guazumifolia</i> essential oil.</p>