Formal Synthesis of (±)-Aplykurodinone‑1 through a Hetero-Pauson–Khand Cycloaddition Approach
2017-02-20T20:50:12Z (GMT) by
The tricyclic intermediate <b>2</b> has been synthesized in eight steps from known compound <b>6</b> in 20% overall yield. As such, this constitutes a highly efficient formal synthesis of (±)-aplykurodinone-1. This synthesis features a unique, one-pot, intramolecular hetero-Pauson-Khand reaction (<i>h</i>-PKR)/desilylation sequence to expeditiously construct the tricyclic framework, providing valuable insights for expanding the scope and boundaries of <i>h</i>-PKR.
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