posted on 2011-12-30, 15:54authored byRainer König, Gunnar Schramm, Marcus Oswald, Hanna Seitz, Sebastian Sager, Marc Zapatka, Gerhard Reinelt, Roland Eils
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Taken from "Discovering functional gene expression patterns in the metabolic network of with wavelets transforms"
Green boxes indicate significant up-regulation (p-value ≤ 0.05) under anaerobic conditions. Red boxes indicate significant down-regulation and grey boxes non-significant differential regulation. Red/green frames of grey boxes indicate a non-significant tendency. Glucose is catabolised into pyruvate. Under anaerobic conditions, pyruvate is degraded to formic acid (formate), which is either expelled (via transporters), or further degraded into Hand CO. The reactions for these processes were up-regulated whereas the biosynthesis and degradation of costly compounds were down-regulated (folate and 10-formyl-THF, respectively).