Fig S4. Conservation of functionally important McrA residues including ligand cavity sites and F420, CoB, and CoM binding sites as revealed by Ermler et al. (21)

The alignment has been trimmed for better view. The residue numbering system follows Ermler et al. (21) and the corresponding positions in Ca. M. hydrogenus Bin16 were marking at the top of the alignment. Conventional McrA were marked in blue, divergent ones were marked in purple and Ca. Methanomixophus were marked in red.