Facile Fabrication of Hierarchical Flower-Like BSA/Layered Double Hydroxide Hybrids

This work presents the synthesis of hierarchical flower-like bovine serum albumin/layered double hydroxides (BSA/LDH) hybrids based on the assembly of biological proteins and LDH nanosheets. The BSA/alumina sols are first obtained by a sol-gel process, followed by self-assembling into spherical aggregates. These preformed hybrid sols are then used as biohybrid precursors and aluminum sources to fabricate the hierarchical architectures based on in situ growth of LDH nanoplatelets around biomolecules. The facile method is expected to be used for fabricating other hierarchical bioinorganic hybrids for potential application in the areas of biocatalysts and drug delivery.