Facile Syntheses of Enantiopure 3-Hydroxypiperidine Derivatives and 3-Hydroxypipecolic Acids

Facile syntheses of enantiopure <i>trans</i>- and <i>cis</i>-3-hydroxypiperidine derivatives and 3-hydroxypipecolic acids are reported, featuring Rh-catalyzed cyclohydrocarbonylation through common intermediates. A diaxial conformation in a 2,3-disubstituted <i>N</i>-Boc-piperidinyl structure is revealed by an X-ray crystallographic analysis.