Experimental design and computational model.

<p><b>(A)</b> Experimental design for data collection and measurement on the 28 Non-Human Primate. All the datasets are available online as Supporting Information (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004804#pcbi.1004804.s013" target="_blank">S2</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004804#pcbi.1004804.s017" target="_blank">S6</a> Tables). <b>(B)</b> Schematic representing the three compartments captured by our computational model. The emphasis is on describing all the lymphocyte phenotypes (both CD4+ and CD8+) tracked during the analysis. The cells populate three different compartments/organs: lung, lymph node and blood. The lung is modeled as an Agent-Based Model (ABM), while the blood and the lymph node are modeled as an Equation-Based Model (EBM), namely as an Ordinary Differential Equation (ODE) system. For most of the phenotypes, both Mtb-specific (colored) and non Mtb-specific (grey) cells are tracked. APC: represented as a proxy in the computational model (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004804#sec009" target="_blank">Materials and Methods</a> section and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004804#pcbi.1004804.s001" target="_blank">S1</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004804#pcbi.1004804.s002" target="_blank">S2</a> Texts for details).</p>