Expedient Strategy for the Synthesis of 5-Acylethynylpyrrole-2-carbaldehydes

N. Tomilin, Denis; N. Sobenina, Lyubov; V. Markova, Marina; D. Gotsko, Maxim; Ushakov, Igor A.; I. Smirnov, Vladimir; V. Vaschenko, Alexander; Mikhaleva, Albina I.; Trofimov, Boris A.

doi:10.6084/m9.figshare.1378940.v3

lsyc_a_1034873_sm3768.pdf (989.19 kB)

Expedient Strategy for the Synthesis of 5-Acylethynylpyrrole-2-carbaldehydes

Version 3 2015-06-10, 18:43

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journal contribution

posted on 2015-06-10, 18:43 authored by Denis N. Tomilin, Lyubov N. Sobenina, Marina V. Markova, Maxim D. Gotsko, Igor A. Ushakov, Vladimir I. Smirnov, Alexander V. Vaschenko, Albina I. Mikhaleva, Boris A. Trofimov

5-Acylethynylpyrrole-2-carbaldehydes have been synthesized from the protected pyrrole-2-carbaldehydes by their transition-metal-free topochemical mechanoactivated ethynylation with acylbromoacetylenes in a solid Al₂O₃ medium (room temperature, 6 h, 41–54% yields).