Expansion of enterocytes expressing IL-15 in intestinal mucosa of paediatric patients with IBD.
Enterocytes were identified as EpCam positive cells. (A) The percentage of EpCam positive cells, and (B) IL-15 and EpCam double positive cells were evaluated in freshly isolated intestinal cells, at basal condition without in vitro mitogen stimulation. Each point represents the percentage of positive cells from one single subject.(C) Flowcytometry dot plots of IL-15 and EpCam stained cells are reported from one representative subject of each group (CD, UC, HC). Horizontal bars are the median values. The Mann-Whitney U test was applied to evaluate statistical significant differences.