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Eunicidiol, an Anti-inflammatory Dilophol Diterpene from Eunicea fusca
journal contribution
posted on 2012-07-27, 00:00 authored by Douglas
H. Marchbank, Fabrice Berrue, Russell G. KerrA new dilophol diterpene, eunicidiol (1),
has been isolated from the crude extract of Eunicea fusca, a gorgonian coral collected from Hillsboro Ledge, Florida. This
compound was purified, along with fuscol (2) and eunicol
(3), using a combination of normal- and reversed-phase
chromatography methods. The structure of eunicidiol (1) was elucidated by 1D and 2D NMR spectroscopic analysis, and the
absolute configuration was assigned using Mosher’s method.
The anti-inflammatory activity of 1–3 was evaluated by measuring their ability to reduce phorbol myristate
acetate (PMA)-induced edema in a mouse ear model. Topical application
of a 100 μg/ear dose of diterpenes 1–3 significantly reduced edema by 44%, 46%, and 54%, respectively.
This activity was superior to indomethacin, a known anti-inflammatory
used as a control.
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Hillsboro LedgeabilityMosherdilophol diterpeneedemaDilopholmouse ear modelindomethacingorgonianeunicidiolchromatography1 DcrudemethodPMADiterpenecombinationTopical applicationcompoundFloridaphorbol myristate acetateconfiguration2 D NMR spectroscopic analysisEunicea fuscaAdoseEunicea fuscaeunicolEunicidiolfuscol
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