Enantioselective Total Synthesis of (−)-Curcuquinone via Regioselective Chromium-Mediated Benzannulation
2005-04-29T00:00:00Z (GMT) by
A short and efficient, high-yielding enantioselective total synthesis of the marine natural product (−)-curcuquinone <b>1</b> is reported involving a regioselective [3 + 2 + 1]-benzannulation reaction as the key step. Additionally, this strategy allows the isolation of curcuhydroquinone monomethyl ether <b>9</b> as an intermediate of the benzannulation reaction and its subsequent further protection toward diversified hydroquinones.
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