Enantioselective Palladium-Catalyzed Allylic Alkylation Using <i>E</i>- and <i>Z</i>-Vinylogous Sulfonates

1999-10-16T00:00:00Z (GMT) by P. Andrew Evans Thomas A. Brandt
The <i>E</i>- and <i>Z</i>-vinylogous sulfonates of β-phenylcinnamyl alcohol derivatives <b>1</b> and <b>2</b> undergo rapid and enantioselective palladium-catalyzed allylic alkylation (≥90% ee) with the palladium complex of the phosphino-1,3-oxazine <b>3</b> and sodium salt of dimethyl malonate.