Enantioselective Organocatalytic Double
Michael Addition Reactions

Li, Hao; Zu, Liansuo; Xie, Hexin; Wang, Jian; Jiang, Wei; Wang, Wei

doi:10.1021/ol070581y.s002

ol070581y_si_002.pdf (3.26 MB)

Enantioselective Organocatalytic Double Michael Addition Reactions

journal contribution

posted on 2007-04-26, 00:00 authored by Hao Li, Liansuo Zu, Hexin Xie, Jian Wang, Wei Jiang, Wei Wang

A novel organocatalytic, enantioselective domino double Michael addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2-butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.