Effects of oral administration of EECA on the hot plate model.

Control groups were composed either the vehicle or morphine (2.5 mg/kg, p.o.). Results are presented as mean ± S.D. (n = 6–10) of increase in baseline or area under the curve. Statistical significance was calculated using ANOVA with Bonferroni’s test where *< 0.005 when comparing the morphine, EECA-treated mice with the vehicle-treated group and #< 0.005 when comparing morphine-treated with EECA-treated mice. Where no error bars are shown, is the result of values being too small to be visible in the graphic.