ppat.1007323.g002.tif (196.2 kB)
Effect of prion infection on weight gain over the incubation period of disease.
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posted on 2018-10-18, 18:08 authored by Thomas E. Eckland, Ronald A. Shikiya, Jason C. BartzHamsters were inoculated with either uninfected brain homogenate (blue triangles), DY-infected brain homogenate (orange diamonds), 139H-infected brain homogenate (gray circles) or an equal mixture of 139H and DY-infected brain homogenate (yellow squares) and their weights were recorded weekly. Solid grey triangle and open yellow triangle indicates when the weight of 139H-infected or 139H/DY co-infected hamsters, respectively, significantly (p<0.05) differed from mock-infected animals.
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prion conversion efficiencylong-incubation period strainsPrion strain interference influences prion strain dynamicsshort-incubation period strainPrP Cprion strainsstrain interferenceprotein misfolding cyclic amplification strain interferenceconversion efficiency prion strains Prion diseasesImportantly PMCA reactionsanimal bioassay studieslong-incubation period strainPrP Sc
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