la6b02118_si_001.pdf (1.95 MB)
Effect of Molecular Structure on Stability of Organic Nanoparticles Formed by Bodipy Dimers
journal contribution
posted on 2016-08-29, 00:00 authored by Wenhai Lin, Wei Zhang, Tingting Sun, Jingkai Gu, Zhigang Xie, Xiabin JingThe
objective was to evaluate the stability of organic nanoparticles
made from Bodipy dimers. Bodipy dimers with different length of linkers
were synthesized via multicomponent Passerini reaction, and could
form the fluorescent nanoparticles (FNPs) through nanoprecipitation.
Bodipy-dimers FNPs with long chain linker indicated better stability
in biological condition than those with short one as revealed by changes
of diameter and size distribution. The FNPs possessed high physical
homogeneity and low cytotoxicity. The molecular structure dependent
stability was also validated by confocal laser scanning microscope
based on the dissociation-induced fluorescence recovering. Importantly,
stable FNPs also could be used to load hydrophobic cargoes and deliver
them into cytoplasm. We believe this systematic study between structure
and stability might open new opportunities for designing stable nanoparticles
for various applications.