Effect of IL-1β, tumor necrosis factor alpha (TNF-α) and IL-17 used alone and in combination on C-Jun translocation

<p><b>Copyright information:</b></p><p>Taken from "Increased AP-1 and NF-κB activation and recruitment with the combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes"</p><p>Arthritis Research & Therapy 2004;6(3):R190-R198.</p><p>Published online 26 Feb 2004</p><p>PMCID:PMC416439.</p><p>Copyright © 2004 Granet et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.</p> Rheumatoid arthritis synoviocytes were stimulated for 30 min with cytokines at the cited concentrations. Cells were fixed in 4% paraformadehyde and immunofluorescence staining was performed. Results are representative of three independent experiments. Effects of proinflammatory cytokines used alone at low and optimal concentrations and in combination on C-Jun nuclear translocation after 30 min of exposure are shown.