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Table 2.xls (5.5 kB)

EC50 values (μM) of BNIP derivatives and nifurtimox against T. cruzi epimastigotes, wild-type (WT) and cells overexpressing TcSir2rp1 (OE) with the pTcINDEX.

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posted on 2018-01-22, 18:31 authored by Luís Gaspar, Ross P. Coron, Paul KongThoo Lin, David M. Costa, Begoña Perez-Cabezas, Joana Tavares, Meritxell Roura-Ferrer, Isbaal Ramos, Céline Ronin, Louise L. Major, Fabrice Ciesielski, Iain K. Pemberton, Jane MacDougall, Paola Ciapetti, Terry K. Smith, Anabela Cordeiro-da-Silva

EC50 values (μM) of BNIP derivatives and nifurtimox against T. cruzi epimastigotes, wild-type (WT) and cells overexpressing TcSir2rp1 (OE) with the pTcINDEX.

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    PLOS Neglected Tropical Diseases

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    NADprotein 1TcSIR 2rp modelreference drug benznidazolep 53 peptide substrateTcSir 2rp overexpressing epimastigotesTrypanosoma cruzi sirtuinsMedicinal chemistry modificationsparasite sirtuin inhibitorsChagas disease Chagas diseaseanti-parasitic activitycruzi Sir 2sirtuin inhibitor nicotinamideTcSir 2rpSilent information regulator 2Trypanosoma cruzi Sir 2compound BNIP Spermidine

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