Eighteen compounds, including eight
new cassane-type furanoditerpenoids,
3β-hydroxyphanginin H (1), 3β-acetoxyphanginin
H (2), 7β-acetoxyphanginin H (3),
7β-hydroxyphanginin H (4), 4-epi-3β-hydroxycaesalpinilinn (5), 4-epi-3β-acetoxycaesalpinilinn (6), 20-acetoxytaepeenin
D (7), and tomocin E (8), along with 10
known compounds (9–18) were isolated
from the roots of Caesalpinia decapetala. Compounds 1–13 were isolated from C. decapetala for the first time. The new compounds with their absolute configurations
were determined by extensive spectroscopic analysis, single-crystal
X-ray diffraction, and electronic circular dichroism calculations.
Compounds 1, 4, 5, 7, and 11 exhibited inhibitory activities against the
SW1990 human pancreatic cancer cell line with IC50 values
ranging from 2.9 to 8.9 μM.