Fig 1.tif (251.8 kB)
Distributions of p values for disease associations of HLA-DRB variants.
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posted on 2016-02-26, 09:51 authored by Kwangwoo Kim, So-Young Bang, Dae Hyun Yoo, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Young Mo Kang, Chang-Hee Suh, Seung-Cheol Shim, Shin-Seok Lee, Jisoo Lee, Won Tae Chung, Seong-Kyu Kim, Jung-Yoon Choe, Swapan K. Nath, Hye-Soon Lee, Sang-Cheol BaeP values for all variants of HLA-DRB1, HLA-DRB3, HLA-DRB4 and HLA-DRB5 were calculated by unconditional and conditional analyses testing associations with RA and SLE. The most significant association in unconditional analyses was identified at HLA-DRβ1 amino-acid position (AA) 11 and AA13 in both RA (A) and SLE (C). After conditioning on all reported disease-associated amino-acid positions of HLA-DRβ1 (11, 13, 71, and 74 in RA and 11, 13, and 26 in SLE), no additional association with p < 5 × 10−8 was identified in RA (B) or SLE (D). Variants with the lowest p value are shown for each HLA-DRB gene.
