Direct Generation of Ti-Enolate of α-CF3 Ketone:  Theoretical Study and
High-Yielding and Diastereoselective Aldol Reaction

Itoh, Yoshimitsu; Yamanaka, Masahiro; Mikami, Koichi

doi:10.1021/ja046518a.s002

ja046518a_si_002.pdf (217.81 kB)

Direct Generation of Ti-Enolate of α-CF₃ Ketone: Theoretical Study and High-Yielding and Diastereoselective Aldol Reaction

journal contribution

posted on 2004-10-20, 00:00 authored by Yoshimitsu Itoh, Masahiro Yamanaka, Koichi Mikami

Success in the direct generation of the Ti-enolate of α-CF₃ ketone and its aldol reaction is reported. The importance of Ti−F interaction during the course of the reaction is also reported.

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generation Ti importance CF Ketone aldol reaction interaction Diastereoselective Aldol Reaction Success ketone Direct Generation

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Direct Generation of Ti-Enolate of α-CF3 Ketone: Theoretical Study and High-Yielding and Diastereoselective Aldol Reaction