Differences in sensitivity to doxorubicin, as measured using clonogenic assays for MCF-7<sub>CC-12</sub> cells stably or transiently transfected with various constructs.

<p>Survival curves are depicted for: <b>(A)</b> stable clones of MCF-7<sub>CC-12</sub> cells transfected with pAKR1C3-FLAG, <b>(B)</b> MCF-7<sub>CC-12</sub> cells, with or without transient transfection with the pAKR1C3-FLAG plasmid, <b>(C)</b> MCF-7<sub>DOX2-12</sub> cells, with or without transient transfection with scrambled or <i>AKR1C3</i>-specific siRNAs, <b>(D)</b> MCF-7<sub>DOX2-12</sub> cells, with or without transient transfection with scrambled or <i>AKR1B10</i>-specific siRNAs, <b>(E)</b> MCF-7<sub>DOX2-12</sub> cells, with or without transient transfection with scrambled or <i>both AKR1C3</i>- and <i>AKR1B10</i>-specific siRNAs.</p>