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Differences in sensitivity to doxorubicin, as measured using clonogenic assays for MCF-7CC-12 cells stably or transiently transfected with various constructs.

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posted on 2017-02-14, 19:22 authored by Simon Chewchuk, Baoqing Guo, Amadeo Mark Parissenti

Survival curves are depicted for: (A) stable clones of MCF-7CC-12 cells transfected with pAKR1C3-FLAG, (B) MCF-7CC-12 cells, with or without transient transfection with the pAKR1C3-FLAG plasmid, (C) MCF-7DOX2-12 cells, with or without transient transfection with scrambled or AKR1C3-specific siRNAs, (D) MCF-7DOX2-12 cells, with or without transient transfection with scrambled or AKR1B10-specific siRNAs, (E) MCF-7DOX2-12 cells, with or without transient transfection with scrambled or both AKR1C3- and AKR1B10-specific siRNAs.

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    doxorubicin resistancebreast tumor cells Intrinsiccontrol MCF -7 CC cellsAKR 1Cgene transcript levelcyclin D 1 expressionE 2 synthesisAKR 1B overexpressioncell proliferation experimentsE 2-dependent controlAKR overexpression actsMCF -7 breast tumor cellsE 2 productionE 2-dependent expressioncell cycle-dependent kinasesMCF -7 CC cellsE 2-dependent pathwaysERanthracycline chemotherapy drugsE 2-related genesE 2 pathwaysBcl -2anthracycline resistanceMCF -7 DOX 2proteinMCF -7 EPI cellsbreast tumor cellsAKR expression

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